The HRA UK has released an update specifying that CTIMP applications via combined review must be submitted using a new part of the Integrated Research Application System (IRAS) and should not be started in the standard part of IRAS. Creating new applications using the standard IRAS system will be disabled from  14 December 2021.

An updated detailed guidance has been released for the step by step guide to using IRAS for combined review.  The guidance comprehensively covers the details required for the creation of an IRAS account, the roles, and tasks of IRAS users, the process of initial submission, and subsequent amendments.